Identification of the ferroptosis regulator HELLS with prognostic value for adrenocortical carcinoma based on integrated analysis and experimental validation

Background: For adrenocortical carcinoma (ACC), a rare endocrine malignancy with high rate of mortality and recurrence, it is difficult for clinicians to predict overall survival select the most effective treatment. Targeting ferroptosis, form cell death, has been reported be promising therapeutic strategy ACC; however, core ferroptosis regulator its prognostic value in ACC remain unknown.